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AI-driven variant interpretation in less than 2 minutes

Dramatically increase throughput and diagnostic yield using our automated genetic variant interpretation platform AION.

benefits

Why AION?

AION allows you to confidently scale your genomic sequencing operations by tackling the interpretation bottleneck.

Fast & Automated

AION provides an exome interpretation in less than 2 minutes. In addition, a comprehensive report and results export are automatically generated.

White-box Approach

We believe that any AI prediction must be verifiable by a human expert. Therefore, AION provides insights into "how" and "why" variants were classified and prioritized.

Accurate Decision Support

Our unique AI-based platform provides accurate and reliable decision-support that outperforms rules-based ACMG classification by more than 50%.

PROCESS

How does it work?

We combine an intuitive design with in-depth reporting to provide outstanding performance.

step 1

Submit case data

Upload a VCF file and define patient characteristic.

step 2

Review results

Get a list of the top 10 variants including the associated disease. Our unique white-box approach allows you to understand the underlying factors contributing to the classification of a variant as pathogenic or benign.

step 3

Get full report

Receive a full report with all relevant information. You can get it either as a PDF, as a CSV export or via our API.

why us?

Our unique approach

Transparent AI discovering
causative variants

Our AI provides a list of causative variants in a auditable and reproducible manner. It learns from new data, but also benefits from expert knowledge: In addition to 30+ data sources, we have modelled a decade of experience in clinical genetics.

Curated, regularly updated
genomic repository

Regularly updated knowledge database with more than 100 annotations, including a selection of data from high-throughput functional genomics assays that directly reflect the molecular impact of thousands of selected mutations.

Performance

Outstanding performance

By combining state-of-the-art artificial intelligence with our regularly updated knowledge base, AION outperforms the rule-based ACMG classification by more than 50%.

The right diagnosis at the right time

For people with genetic diseases, getting the right diagnosis at the right time is critical. With AION you can speed up large parts of your variant interpretation, focus on very complex cases and build a sustainable business.

2min

AION automatically identifies likely pathogenic variants in less than 2 minutes.

>50%

AION can improve diagnostic yield by more than 50% compared to a rules-based ACMG classification.

100+

AION is based on a vast, regularly updated and extended database containing >100 annotations.

Read our white paper to learn more about AION

Download our white paper to learn how AION’s white-box approach can help you improve the quality and throughput of your variant interpretation.

Find out more about AION in our white paper

Download our white paper to find out how AION’s white-box approach can help you to improve the quality and throughput of your variant interpretation.

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AION is easy to use and doesn’t require any integration.

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AION's architecture and procedures are designed to provide the highest standards of security and privacy.

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